Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1

@inproceedings{Iijima2014NeuronalCT,
  title={Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1},
  author={Takatoshi Iijima and Yoko Iijima and Harald Witte and Peter Scheiffele},
  booktitle={The Journal of cell biology},
  year={2014}
}
The unique functional properties and molecular identity of neuronal cell populations rely on cell type-specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain-containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1… CONTINUE READING