Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing.

Abstract

In search for physiological pathways affecting alternative splicing through its kinetic coupling with transcription, we found that membrane depolarization of neuronal cells triggers the skipping of exon 18 from the neural cell adhesion molecule (NCAM) mRNA, independently of the calcium/calmodulin protein kinase IV pathway. We show that this exon responds to… (More)
DOI: 10.1073/pnas.0810666106

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