Neuronal caspase-3 signaling: not only cell death

  title={Neuronal caspase-3 signaling: not only cell death},
  author={Marcello D'Amelio and Virve Cavallucci and Francesco Cecconi},
  journal={Cell Death and Differentiation},
Caspases are a family of cysteinyl aspartate-specific proteases that are highly conserved in multicellular organisms and function as central regulators of apoptosis. A member of this family, caspase-3, has been identified as a key mediator of apoptosis in neuronal cells. Recent studies in snail, fly and rat suggest that caspase-3 also functions as a regulatory molecule in neurogenesis and synaptic activity. In this study, in addition to providing an overview of the mechanism of caspase-3… CONTINUE READING

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