Neuronal calcium sensor 1 and activity-dependent facilitation of P/Q-type calcium currents at presynaptic nerve terminals.

@article{Tsujimoto2002NeuronalCS,
  title={Neuronal calcium sensor 1 and activity-dependent facilitation of P/Q-type calcium currents at presynaptic nerve terminals.},
  author={Tetsuhiro Tsujimoto and Andreas Jeromin and Naoto Saitoh and John C. C. Roder and Tomoyuki Takahashi},
  journal={Science},
  year={2002},
  volume={295 5563},
  pages={2276-9}
}
P/Q-type presynaptic calcium currents (IpCa) undergo activity-dependent facilitation during repetitive activation at the calyx of the Held synapse. We investigated whether neuronal calcium sensor 1 (NCS-1) may underlie this phenomenon. Direct loading of NCS-1 into the nerve terminal mimicked activity-dependent IpCa facilitation by accelerating the activation time of IpCa in a Ca2+-dependent manner. A presynaptically loaded carboxyl-terminal peptide of NCS-1 abolished IpCa facilitation. These… CONTINUE READING
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