Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

@article{Evans2011NeuronalBN,
  title={Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.},
  author={Sarah Felice Evans and Krithi Irmady and Katya Ostrow and Taeho Kim and Anders Nykjaer and Paul Saftig and Carl P Blobel and Barbara L. Hempstead},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 34},
  pages={29556-67}
}
Brain-derived neurotrophic factor (BDNF) regulates neuronal differentiation, synaptic plasticity, and morphology, and modest changes in BDNF levels results in complex behavioral phenotypes. BDNF levels and intracellular localization in neurons are regulated by multiple mechanisms, including use of distinct promoters, mRNA and protein transport, and regulated cleavage of proBDNF to mature BDNF. Sortilin is an intracellular chaperone that binds to the prodomain of BDNF to traffic it to the… CONTINUE READING

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