Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

@article{Lee2005NeuronalAL,
  title={Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.},
  author={Sungwoo Lee and Eijiro Nakamura and Haifeng Yang and Wenyi Wei and Michelle S Linggi and Mini P. Sajan and Robert V Farese and Robert S Freeman and Bruce D Carter and William G Kaelin and Susanne Schlisio},
  journal={Cancer cell},
  year={2005},
  volume={8 2},
  pages={
          155-67
        }
}
Germline NF1, c-RET, SDH, and VHL mutations cause familial pheochromocytoma. Pheochromocytomas derive from sympathetic neuronal precursor cells. Many of these cells undergo c-Jun-dependent apoptosis during normal development as NGF becomes limiting. NF1 encodes a GAP for the NGF receptor TrkA, and NF1 mutations promote survival after NGF withdrawal. We found that pheochromocytoma-associated c-RET and VHL mutations lead to increased JunB, which blunts neuronal apoptosis after NGF withdrawal. We… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 228 CITATIONS

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 25 Highly Influenced Citations

  • Averaged 10 Citations per year over the last 3 years

Similar Papers

Loading similar papers…