Neuronal apoptosis in HIV infection in adults

@article{AdleBiassette1995NeuronalAI,
  title={Neuronal apoptosis in HIV infection in adults},
  author={Homa Adle-Biassette and Yves L{\'e}vy and M. Colornbel and F. Poron and Sevdalin Natchev and Catherine Keohane and Françoise Gray},
  journal={Neuropathology and Applied Neurobiology},
  year={1995},
  volume={21}
}
Productive infection of the central nervous system by HIV predominantly involves the white matter and basal ganglia. Involvement of the cerebral cortex with neuronal loss is also described in AIDS patients but not in asymptomatic HIV‐positive patients. The mechanism of neuronal damage is unknown. To enquire whether neuronal loss in AIDS may be due to an apoptotic process, we examined the cerebral cortex from 12 patients who died from AIDS using two different methods: in situ end labelling and… 

Neuronal apoptosis in human immunodeficiency virus infection.

It is concluded that neuronal apoptosis and consequent neuronal loss, in HIV infected patients, are probably not related to a single cause and it seems likely that microglial activation, directly or indirectly related to HIV infection of the CNS, plays a major role in its causation possibly through the mediation of oxidative stress.

Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage

There was an obvious topographic correlation supporting the view that axonal damage, either secondary to local microglial activation or due to the intervention of systemic factors, may also contribute to neuronal apoptosis.

Programmed cell death in brains of HIV-1-positive AIDS and pre-AIDS patients

The presence of apoptotic cells in a number, albeit small, of brains of HIV-1-positive pre-AIDS individuals, combined with abnormalities described previously in the same group of patients, gives further support to the opinion that brain damage already occurs during the early stages of HIV infection.

Neuropathogenesis of central nervous system HIV-1 infection.

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