Neuronal apoptosis in HIV infection in adults

  title={Neuronal apoptosis in HIV infection in adults},
  author={Homa Adle-Biassette and Yves L{\'e}vy and M. Colornbel and F. Poron and Sevdalin Natchev and Catherine Keohane and Françoise Gray},
  journal={Neuropathology and Applied Neurobiology},
Productive infection of the central nervous system by HIV predominantly involves the white matter and basal ganglia. Involvement of the cerebral cortex with neuronal loss is also described in AIDS patients but not in asymptomatic HIV‐positive patients. The mechanism of neuronal damage is unknown. To enquire whether neuronal loss in AIDS may be due to an apoptotic process, we examined the cerebral cortex from 12 patients who died from AIDS using two different methods: in situ end labelling and… 

Neuronal apoptosis in human immunodeficiency virus infection.

It is concluded that neuronal apoptosis and consequent neuronal loss, in HIV infected patients, are probably not related to a single cause and it seems likely that microglial activation, directly or indirectly related to HIV infection of the CNS, plays a major role in its causation possibly through the mediation of oxidative stress.

Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage

There was an obvious topographic correlation supporting the view that axonal damage, either secondary to local microglial activation or due to the intervention of systemic factors, may also contribute to neuronal apoptosis.

Programmed cell death in brains of HIV-1-positive AIDS and pre-AIDS patients

The presence of apoptotic cells in a number, albeit small, of brains of HIV-1-positive pre-AIDS individuals, combined with abnormalities described previously in the same group of patients, gives further support to the opinion that brain damage already occurs during the early stages of HIV infection.

Neuropathogenesis of central nervous system HIV-1 infection.

  • D. Kolson
  • Biology
    Clinics in laboratory medicine
  • 2002

Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration

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The shifting patterns of HIV encephalitis neuropathology

More detailed characterization of these proposed variants of HIVE is important in order to better understand the pathogenesis of HIV-associated neurological damage and to design more effective treatments to protect the nervous system.

Damage and Repair of DNA in HIV Encephalitis

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HIV and the Nervous System ‐ Part I

Data from the authors' own PCR-ISH studies on peripheral nerve indicate that Schwann cells, both in nerve faxiculi and dorsal root ganglia, may be an important step in the pathogenesis of DPSN, which is latently infected by HIV.



Immunohistochemical Changes and PCR Detection of HIV Provirus DNA in Brains of Asymptomatic HIV-Positive Patients

Results show that HIV proviral DNA can be found in the brains of HIV-positive non- AIDS patients and in the same group there is an increase in density of microglial cells which appears to be transient, since AIDS brains without neuropathology show a lower density of these cells.

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

It is suggested that the neuronal deficits associated with HIV may not be entirely a result of infectivity, but that gp120 shed from HIV could directly produce the neuropathology as a consequence of its interference with endogenous neurotrophic substances.

A Review of Neuronal Damage in Human Immunodeficiency Virus Infection: Its Assessment, Possible Mechanism and Relationship to Dementia

The modern stereological procedures available for quantitative investigations; the pattern, degree and time scale of HIV-associated neuronal loss; thirdly, other morphological evidence of neuronal damage; and the pathological and clinical implications of these findings are reviewed.

Early Brain Changes in HIV Infection: Neuropathological Study of 11 HIV Seropositive, Non‐AIDS Cases

The view that early central nervous system changes occur in HIV infection is supported, as complete postmortem examination did not show evidence of acquired immune deficiency syndrome (AIDS) or AIDS related complex.

Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice

In vivo evidence is provided that gp120 plays a key part in HIV-1-associated nervous system impairment and this model should facilitate the evaluation and development of therapeutic strategies aimed at HIV–brain interactions.

Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains.

Increased tissue levels of TNF-alpha and QUIN may have a role in the etiology of HIV-related neurologic dysfunction, and brain tissue and CSF QUIN concentrations were substantially increased compared to control values.

HIV‐Related Neurotoxicity

Evidence is presented for HIV‐related toxic factors that may account at least in part for neuronal injury in AIDS, and for gp120‐induced neurotoxicity, which can be prevented by antagonists of L‐type voltage‐dependent calcium channels or by antagonist of W‐methyl‐D‐aspartate.

Neocortical damage during HIV infection

Qualitative and quantitative assessments of neocortical neuropil reveal a loss of synaptic density and vacuolation of dendritic processes, and statistically significant thinning of the neocortex, with a Loss of large cortical neurons in patients with HIV encephalitis.