Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.

@article{Borges2003NeuronalAG,
  title={Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.},
  author={Karin Borges and Marla Gearing and Dayna L McDermott and Amy B. Smith and Antoine G Almonte and Bruce H. Wainer and Raymond J Dingledine},
  journal={Experimental neurology},
  year={2003},
  volume={182 1},
  pages={21-34}
}
The rodent pilocarpine model of epilepsy exhibits hippocampal sclerosis and spontaneous seizures and thus resembles human temporal lobe epilepsy. Use of the many available mouse mutants to study this epilepsy model would benefit from a detailed neuropathology study. To identify new features of epileptogenesis, we characterized glial and neuronal pathologies after pilocarpine-induced status epilepticus (SE) in CF1 and C57BL/6 mice focusing on the hippocampus. All CF1 mice showed spontaneous… CONTINUE READING
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