Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62.

@article{Arai2003NeuronalAG,
  title={Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62.},
  author={Tetsuaki Arai and Takashi Nonaka and Masato Hasegawa and Haruhiko Akiyama and Mari Yoshida and Yosio Hashizume and Kuniaki Tsuchiya and Tatsuro Oda and Kenji Ikeda},
  journal={Neuroscience letters},
  year={2003},
  volume={342 1-2},
  pages={41-4}
}
We examined the immunoreactivity of p62 in five cases of frontotemporal dementia (FTD) with ubiquitin-positive, tau-negative inclusions. Only one case had clinical features suggestive of motor neuron disease (MND). In all cases, ubiquitin-positive neuronal inclusions and neurites in the hippocampal region and cerebral neocortex were immunohistochemically positive for p62. Moreover, in the temporal region of a case of FTD with MND, many oligodendrocytes and some astrocytes were positive for p62… CONTINUE READING

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