Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis.

  title={Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis.},
  author={Patrizia Proia and Gabriella Schiera and Giuseppe Salemi and Paolo Ragonese and Giovanni Savettieri and Italia Di Liegro},
  journal={International journal of molecular medicine},
  volume={24 6},
An important component of the pathogenic process of multiple sclerosis (MS) is the blood-brain barrier (BBB) damage. We recently set an in vitro model of BBB, based on a three-cell-type co-culture system, in which rat neurons and astrocytes synergistically induce brain capillary endothelial cells to form a monolayer with permeability properties resembling those of the physiological BBB. Herein we report that the serum from patients with secondary progressive multiple sclerosis (SPMS) has a… 

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