Neuronal activity regulates glutamate transporter dynamics in developing astrocytes.

@article{Benediktsson2012NeuronalAR,
  title={Neuronal activity regulates glutamate transporter dynamics in developing astrocytes.},
  author={Adrienne M Benediktsson and Glen S Marrs and J. C. Tu and Paul F Worley and Jeffrey D Rothstein and Dwight E Bergles and Michael E. Dailey},
  journal={Glia},
  year={2012},
  volume={60 2},
  pages={175-88}
}
Glutamate transporters (GluTs) maintain a low ambient level of glutamate in the central nervous system (CNS) and shape the activation of glutamate receptors at synapses. Nevertheless, the mechanisms that regulate the trafficking and localization of transporters near sites of glutamate release are poorly understood. Here, we examined the subcellular distribution and dynamic remodeling of the predominant GluT GLT-1 (excitatory amino acid transporter 2, EAAT2) in developing hippocampal astrocytes… CONTINUE READING