Neuronal activity-regulated gene transcription in synapse development and cognitive function.

  title={Neuronal activity-regulated gene transcription in synapse development and cognitive function.},
  author={Anne E West and Michael E. Greenberg},
  journal={Cold Spring Harbor perspectives in biology},
  volume={3 6}
Activity-dependent plasticity of vertebrate neurons allows the brain to respond to its environment. During brain development, both spontaneous and sensory-driven neural activity are essential for instructively guiding the process of synapse development. These effects of neuronal activity are transduced in part through the concerted regulation of a set of activity-dependent transcription factors that coordinate a program of gene expression required for the formation and maturation of synapses… CONTINUE READING
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Publications referenced by this paper.
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The Journal of neuroscience : the official journal of the Society for Neuroscience • 1996
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