Neuronal activity enhances tau propagation and tau pathology in vivo

  title={Neuronal activity enhances tau propagation and tau pathology in vivo},
  author={Jessica W. Wu and Syed Abid Hussaini and Isle M. Bastille and Gustavo Albi Rodr{\'i}guez and Ana Mrejeru and Kelly C. Rilett and David W. Sanders and Casey N. Cook and Hongjun Fu and Rick A.C.M. Boonen and Mathieu Herman and Eden Nahmani and Sheina Emrani and Y. Helen Figueroa and Marc I Diamond and Catherine L. Taylor Clelland and Selina Wray and Karen E Duff},
  booktitle={Nature Neuroscience},
Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, suggesting that at least one mechanism by which tau can transfer is via the extracellular space. Neuronal activity has been shown to regulate tau secretion, but its effect on tau… CONTINUE READING
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Developmental regulation of tau splicing is disrupted in stem cell - derived neurons from frontotemporal dementia patients with the 10 + 16 splice - site mutation in MAPT

  • K. W. Yoon, D. F. Covey, S. M. Rothman
  • Hum . Mol . Genet .
  • 2015

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