Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.

@article{Zhang2015NeuronalSC,
  title={Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.},
  author={Hua Zhang and Lili Wu and Ekaterina Pchitskaya and Olga Zakharova and Takashi Saito and Takaomi C Saido and Ilya B Bezprozvanny},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 39},
  pages={13275-86}
}
Alzheimer's disease (AD) is the most common reason for elderly dementia in the world. We proposed that memory loss in AD is related to destabilization of mushroom postsynaptic spines involved in long-term memory storage. We demonstrated previously that stromal interaction molecule 2 (STIM2)-regulated neuronal store-operated calcium entry (nSOC) in postsynaptic spines play a key role in stability of mushroom spines by maintaining activity of synaptic Ca(2+)/calmodulin kinase II (CaMKII… CONTINUE READING
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