Neuronal Soluble Factors Differentially Regulate the Expression of the GLT1 and GLAST Glutamate Transporters in Cultured Astroglia

@article{Gegelashvili1997NeuronalSF,
  title={Neuronal Soluble Factors Differentially Regulate the Expression of the GLT1 and GLAST Glutamate Transporters in Cultured Astroglia},
  author={G. Gegelashvili and N. Danbolt and A. Schousboe},
  journal={Journal of Neurochemistry},
  year={1997},
  volume={69}
}
Abstract: The glutamate transporters in the plasma membranes of neural cells secure termination of the glutamatergic synaptic transmission and keep the glutamate levels below toxic concentrations. Astrocytes express two types of glutamate transporters, GLAST (EAAT1) and GLT1 (EAAT2). GLT1 predominates quantitatively and is responsible for most of the glutamate uptake activity in the juvenile and adult brain. However, GLT1 is severely down‐regulated in amyotrophic lateral sclerosis, a… Expand
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