Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.

@article{Lu2013NeuronalSD,
  title={Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.},
  author={Min Lu and David A. Sarruf and Pingping Li and Olivia Osborn and Manuel S{\'a}nchez-Alavez and Saswata Talukdar and Ai Lin Chen and Gautam Kumar Bandyopadhyay and Jianfeng Xu and Hidetaka Morinaga and Kevin Dines and Steven M. Watkins and Karl K Kaiyala and Michael J. Schwartz and Jerrold M. Olefsky},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 15},
  pages={10722-35}
}
Sirt1 is a NAD(+)-dependent class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity plays a role in the central regulation of energy balance and glucose metabolism. To assess this idea, we generated Sirt1 neuron-specific knockout (SINKO) mice. On both standard chow and HFD, SINKO mice were more insulin sensitive than Sirt1(f/f) mice. Thus, SINKO mice had lower… CONTINUE READING