Neuronal Signal Substances as Biomarkers of Migraine

  title={Neuronal Signal Substances as Biomarkers of Migraine},
  author={L. Edvinsson},
  journal={Headache: The Journal of Head and Face Pain},
  • L. Edvinsson
  • Published 2006
  • Medicine
  • Headache: The Journal of Head and Face Pain
  • Of the sensory nervous system associated signal substances it is only calcitonin generelated peptide (CGRP) that is reliably associated with the degree of pain in the acute attacks of primary headaches. The treatment with triptans alleviates both the pain and the associated CGRP release, putatively via a presynaptic effect on the sensory nerves. The studies of opoids and other sensory neuropeptides are inconsistent and require further analysis. Initial positive data on endothelin and its… CONTINUE READING
    21 Citations
    Headache endocrinological aspects.
    • 6
    Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers
    • 30
    Migraine is a neuronal disease
    • 41
    • PDF
    Advances in the pharmacologic treatment of tension-type headache
    • 13
    Migraine: Molecular Basis and Herbal Medicine
    • 6
    • PDF


    The Nitric Oxide Hypothesis of Migraine and Other Vascular Headaches
    • 222
    Raised Plasma Endothelin During Acute Migraine Attack
    • 61
    Regulation of Calcitonin Gene-Related Peptide Secretion by a Serotonergic Antimigraine Drug
    • 167
    • PDF