Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase

@article{Tatum2015NeuronalSR,
  title={Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase},
  author={Marcus Tatum and Felicia K Ooi and Madhusudana Rao Chikka and Laetitia Chauve and Luis A. Martinez-Velazquez and Harry W. M. Steinbusch and Richard I. Morimoto and Veena Prahlad},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={163-174}
}
BACKGROUND Cellular mechanisms aimed at repairing protein damage and maintaining homeostasis, widely understood to be triggered by the damage itself, have recently been shown to be under cell nonautonomous control in the metazoan C. elegans. The heat shock response (HSR) is one such conserved mechanism, activated by cells upon exposure to proteotoxic conditions such as heat. Previously, we had shown that this conserved cytoprotective response is regulated by the thermosensory neuronal circuitry… CONTINUE READING

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