Neuronal PTP1B regulates body weight, adiposity and leptin action

  title={Neuronal PTP1B regulates body weight, adiposity and leptin action},
  author={Kendra K. Bence and Mirela Delibegovi{\'c} and Bingzhong Xue and Cem Z. Gorgun and G{\^o}khan S. Hotamisligil and Benjamin G Neel and Barbara B. Kahn},
  journal={Nature Medicine},
Obesity is a major health problem and a risk factor for type 2 diabetes. Leptin, an adipocyte-secreted hormone, acts on the hypothalamus to inhibit food intake and increase energy expenditure. Most obese individuals develop hyperleptinemia and leptin resistance, limiting the therapeutic efficacy of exogenously administered leptin. Mice lacking the tyrosine phosphatase PTP1B are protected from diet-induced obesity and are hypersensitive to leptin, but the site and mechanism for these effects… CONTINUE READING
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