Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons.

@article{Teh2007NeuronalPD,
  title={Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons.},
  author={Christina Hui-leng Teh and Chin Chieh Loh and Kevin K. Y. Lam and Jia Min Loo and Tie Yan and Tit Meng Lim},
  journal={Journal of neuroscience research},
  year={2007},
  volume={85 8},
  pages={1762-73}
}
Catecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (TH) is the rate-limiting enzyme. Dopamine is the main neurotransmitter present in dopaminergic neurons of the ventral midbrain, where dysfunction of these neurons can lead to Parkinson's disease and schizophrenia. Neuronal PAS domain protein 1 (NPAS1) was identified as one of the genes up-regulated during dopaminergic MN9D cell differentiation. We found that there… CONTINUE READING