Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated.

@article{Richler2011NeuronalPR,
  title={Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated.},
  author={Esther Richler and Eiji Shigetomi and Baljit S. Khakh},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 46},
  pages={16716-30}
}
ATP-gated ionotropic P2X2 receptors are widely expressed in neurons. Although the electrophysiological properties of P2X2 receptors have been extensively studied, little is known about the plasma membrane lateral mobility of P2X2 receptors or whether receptor mobility is regulated by ATP. Here we used single-molecule imaging with simultaneous whole-cell voltage-clamp recordings to track quantum dot-labeled P2X2 receptors in the dendrites of rat hippocampal neurons to explore P2X2 receptor… CONTINUE READING
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