Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum.

@article{Petrinovic2013NeuronalNN,
  title={Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum.},
  author={Marija M. Petrinovic and Raphael Hourez and Elisabeth M Aloy and Gr{\'e}goire Dewarrat and David Gall and Oliver Weinmann and Julien Gaudias and Lukas C Bachmann and Serge N Schiffmann and Kaspar E. Vogt and Martin E. Schwab},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 3},
  pages={
          1083-8
        }
}
Neuronal signal integration as well as synaptic transmission and plasticity highly depend on the morphology of dendrites and their spines. Nogo-A is a membrane protein enriched in the adult central nervous system (CNS) myelin, where it restricts the capacity of axons to grow and regenerate after injury. Nogo-A is also expressed by certain neurons, in particular during development, but its physiological function in this cell type is less well understood. We addressed this question in the… CONTINUE READING

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