Neuronal Mechanisms of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

  title={Neuronal Mechanisms of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia},
  author={V. Castellucci and H. Pinsker and I. Kupfermann and E. Kandel},
  pages={1745 - 1748}
The cellular mechanisms of habituation and dishabituation of the gill-withdrawal reflex in Aplysia were studied with an isolated abdominal ganglion connected to a piece of skin from the tactile receptive field of the reflex. By obtaining simultaneous intracellular recordings from both the sensory neurons and one of the main identified motor neurons, we have been able to reduce the reflex to its monosynaptic components. The monosynaptic excitatory postsynaptic potentials showed a profound low… Expand
Habituation in Aplysia: The Cheshire Cat of neurobiology
  • D. Glanzman
  • Medicine, Biology
  • Neurobiology of Learning and Memory
  • 2009
The demonstration of LTD in vitro opens up a promising new avenue for attempts to relate long-term habituation to cellular changes within the nervous system of Aplysia. Expand
Habituation of reflexes in Aplysia: contribution of the peripheral and central nervous systems.
Repeated electrical stimulation of two efferent nerves to the gill, after removal of the parietovisceral ganglion, resulted in habituation of withdrawal movements, which shows that the terminals of theganglion neurons in the gills are a site of habituation. Expand
Analysis of synaptic depression contributing to habituation of gill-withdrawal reflex in Aplysia californica.
  • J. Byrne
  • Psychology, Medicine
  • Journal of neurophysiology
  • 1982
The results indicate that the recovery of synaptic depression following a train of 10 stimuli is not constant and that there may be a slight underlying facilitatory process with short spike intervals, which is inconsistent with a classical depletion model for synaptic depression. Expand
Contribution of polysynaptic pathways in the mediation and plasticity of Aplysia gill and siphon withdrawal reflex: evidence for differential modulation
  • L. Trudeau, V. Castellucci
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1992
The results indicate that interneurons intercalated between sensory and motor neurons are responsible for a considerable proportion of the afferent input to the motor neurons of the GSW reflex and also indicate that the monosynaptic and polysynaptic components of the reflex can be differentially modulated. Expand
Correlates of Habituation of a Polysynaptic Reflex in Crayfish In Vivo and In Vitro
Findings point to a central locus of habituation upstream from the motorneurons, and offer prospects for a detailed investigation of the mechanisms of habituated in a polysynaptic system. Expand
A cellular mechanism of classical conditioning in Aplysia.
  • R. Hawkins
  • Biology, Medicine
  • The Journal of experimental biology
  • 1984
Results indicate that a mechanism of classical conditioning of the withdrawal reflex is an elaboration of the mechanism underlying sensitization, and the mechanisms of higher-order features of learning, such as the effect of contingency, may be built from combinations of the molecular mechanisms of these simple forms of learning. Expand
Contribution of individual mechanoreceptor sensory neurons to defensive gill-withdrawal reflex in Aplysia.
The results indicate that the known neural elements may quantitatively account for most of the expression of the behavior and its short-term habituation. Expand
The Contribution of Facilitation of Monosynaptic PSPs to Dishabituation and Sensitization of the Aplysia Siphon Withdrawal Reflex
A new simplified preparation for studying the siphon-withdrawal reflex of Aplysia is developed, providing the most direct evidence so far available that both dishabituation and sensitization involve multiple mechanisms, including heterosynaptic facilitation of sensory neuron-motor neuron PSPs. Expand
Protection from habituation of the crayfish lateral giant fibre escape response
Experiments reported here were undertaken to determine whether habituation would occur under circumstances when it would presumably be maladaptive — in particular, when tactile receptors are stimulated by an animal's own tail‐flip movements. Expand
Nonuniform expression of habituation in the activity of distinct classes of neurons in the Aplysia abdominal ganglion
The authors' experiments address the issue of how habituation is expressed in the activity of the population of neurons responding to siphon stimulation by observing global observations of neuronal response in the Aplysia abdominal ganglion using voltage-sensitive dye recording. Expand


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Irving Kupfermann and of the Gill-Withdrawal Reflex in Aplysia Neuronal Mechanisms of Habituation and Dishabituation Editor's Summary This copy is for your personal