Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling

@inproceedings{Lv2015NeuronalMC,
  title={Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling},
  author={D. G. Lv and Yuqing Shen and Yaqin Peng and Jiane Liu and Fengqin Miao and Jianqiong Zhang and Yanmin Yang},
  booktitle={PloS one},
  year={2015}
}
MHC class I (MHC-I) molecules are important components of the immune system. Recently MHC-I have been reported to also play important roles in brain development and synaptic plasticity. In this study, we examine the molecular mechanism(s) underlying activity-dependent MHC-I expression using hippocampal neurons. Here we report that neuronal expression level of MHC-I is dynamically regulated during hippocampal development after birth in vivo. Kainic acid (KA) treatment significantly increases the… CONTINUE READING