Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan

@inproceedings{Oyston2018NeuronalLR,
  title={Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan},
  author={Lisa J Oyston and Yong Qi Lin and Thang Manh Khuong and Qiao-Ping Wang and Man-Tat Lau and Teleri Clark and G Gregory Neely},
  booktitle={Cell stress},
  year={2018}
}
Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria. Here we investigate the role of neuronal Lamin in regulating age-related phenotypes. Neuronal targeting of Lamin led to shortened lifespan, progressive impairment of motor function and loss of dopaminergic (DA) neurons within the protocerebral… CONTINUE READING

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