Neuronal Growth and Formation of Neuron Networks on Directional Surfaces

@article{Yurchenko2021NeuronalGA,
  title={Neuronal Growth and Formation of Neuron Networks on Directional Surfaces},
  author={Ilya Yurchenko and Matthew Farwell and Donovan D. Brady and Cristian Staii},
  journal={Biomimetics},
  year={2021},
  volume={6}
}
The formation of neuron networks is a process of fundamental importance for understanding the development of the nervous system and for creating biomimetic devices for tissue engineering and neural repair. The basic process that controls the network formation is the growth of an axon from the cell body and its extension towards target neurons. Axonal growth is directed by environmental stimuli that include intercellular interactions, biochemical cues, and the mechanical and geometrical… 
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References

SHOWING 1-10 OF 55 REFERENCES
Neuron dynamics on directional surfaces.
TLDR
The dynamics of axonal growth for neuronal cells cultured on micro-patterned polydimethylsiloxane surfaces are analyzed and it is demonstrated that axonal alignment on these substrates is determined by the surface geometry, andit is quantified by the deterministic part of the stochastic equations.
Effects of Surface Asymmetry on Neuronal Growth
TLDR
The observed directional bias in axonal outgrowth is related to cellular contact guidance behavior, which results in an increase in the cell-surface coupling with increased surface anisotropy and could lead to new methods for stimulating neuronal regeneration and the engineering of artificial neuronal tissue.
Distance dependence of neuronal growth on nanopatterned gold surfaces.
TLDR
This work quantitatively and systematically analyzes how neuronal growth depends on different geometrical parameters and uses a previously reported atomic force microscopy (AFM) nanolithography method to control precisely the location and growth of neurons on these surfaces.
Anomalous diffusion for neuronal growth on surfaces with controlled geometries
TLDR
The importance of geometrical cues in guiding axonal growth and dynamics for neuronal cells cultured on patterned polydimethylsiloxane surfaces is demonstrated, and could lead to new methods for bioengineering novel substrates for controlling neuronal growth and regeneration.
Biophysics of substrate interaction: Influence on neural motility, differentiation, and repair
TLDR
This work focuses on the current understanding of how physical cues shape cellular differentiation and migration, and discusses their relevance to repairing the injured nervous system.
Directional guidance of nerve growth cones
Temperature response of the neuronal cytoskeleton mapped via atomic force and fluorescence microscopy
TLDR
The dominant mechanism by which the elasticity of the neurons changes in response to temperature is the stiffening of the actin components of the cytoskeleton induced by myosin II, and this results demonstrate the importance of considering temperature effects when investigating cytoskeletal dynamics in cells.
Molecular mechanisms of axon guidance.
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