Neuronal Functions of ESCRTs

  title={Neuronal Functions of ESCRTs},
  author={Jin-A Lee and Fen-Biao Gao},
  booktitle={Experimental neurobiology},
The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission, microRNA function, viral budding, and the autophagy pathway in many tissues, including the nervous system. Indeed, dysfunctional ESCRTs are associated with neurodegeneration. However, it remains largely elusive how ESCRTs act in post-mitotic neurons, a highly… CONTINUE READING


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