Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span

@article{Bauer2005NeuronalEO,
  title={Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span},
  author={Johannes H. Bauer and Peter C. Poon and Heather R Glatt-Deeley and John M. Abrams and Stephen L. Helfand},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={2063-2068}
}
Hyperactivation of p53 leads to a reduction in tumor formation and an unexpected shortening of life span in two different model systems . The decreased life span occurs with signs of accelerated aging, such as osteoporosis, reduction in body weight, atrophy of organs, decreased stress resistance, and depletion of hematopoietic stem cells. These observations suggest a role for p53 in the determination of life span and the speculation that decreasing p53 activity may result in positive effects on… CONTINUE READING

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