Neuronal Dye-Sorption as a Histochemical Indicator of Nervous Activity

Abstract

PROTEIN extracts from electrically stimulated nervous tissue have been reported to undergo changes resembling those of reversible denaturation1. Denaturation of protein, however, enhances dye-protein interaction2. It was postulated, therefore, that excitation of nervous tissue could be demonstrated histochemically3. 
DOI: 10.1038/1831337a0

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