Neuronal Cyclooxygenase-2 Activity and Prostaglandins PGE2, PGD2, and PGF2α Exacerbate Hypoxic Neuronal Injury in Neuron-enriched Primary Culture

@article{Li2007NeuronalCA,
  title={Neuronal Cyclooxygenase-2 Activity and Prostaglandins PGE2, PGD2, and PGF2α Exacerbate Hypoxic Neuronal Injury in Neuron-enriched Primary Culture},
  author={W. Li and Shasha Wu and R. Hickey and M. Rose and J. Chen and S. Graham},
  journal={Neurochemical Research},
  year={2007},
  volume={33},
  pages={490-499}
}
  • W. Li, Shasha Wu, +3 authors S. Graham
  • Published 2007
  • Medicine, Biology
  • Neurochemical Research
  • Cyclooxygenase-2 (COX-2) activity has been implicated in the pathogenesis of cerebral ischemia. To determine whether COX-2 activity within the neuron itself exacerbates hypoxic neuronal injury, neuron-enriched cultures were subjected to anoxia. Treatment with COX-2 selective antagonists decreased cell death. Neurons cultured from homozygous COX-2 gene disrupted mice were resistant to hypoxia compared to those of heterozygotes. Infection of primary neurons with AAV expressing COX-2 exacerbated… CONTINUE READING
    Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System
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