Neuronal Control of Locomotion in C. elegans Is Modified by a Dominant Mutation in the GLR-1 Ionotropic Glutamate Receptor

@article{Zheng1999NeuronalCO,
  title={Neuronal Control of Locomotion in C. elegans Is Modified by a Dominant Mutation in the GLR-1 Ionotropic Glutamate Receptor},
  author={Yi cheng Zheng and Penelope J. Brockie and Jerry E. Mellem and David M. Madsen and Andres Villu Maricq},
  journal={Neuron},
  year={1999},
  volume={24},
  pages={347-361}
}
How simple neuronal circuits control behavior is not well understood at the molecular or genetic level. In Caenorhabditis elegans, foraging behavior consists of long, forward movements interrupted by brief reversals. To determine how this pattern is generated and regulated, we have developed novel perturbation techniques that allow us to depolarize selected neurons in vivo using the dominant glutamate receptor mutation identified in the Lurcher mouse. Transgenic worms that expressed a mutated C… CONTINUE READING
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