Neuronal Cell Death and Reactive Oxygen Species

  title={Neuronal Cell Death and Reactive Oxygen Species},
  author={Alexander Boldyrev and Renjie Song and Vladimir A. Dyatlov and David S Lawrence and D. E. O. S. Carpenter},
  journal={Cellular and Molecular Neurobiology},
1. We have investigated the role of reactive oxygen species (ROS) in cell death induced by ischemia or application of the excitatory amino acid agonist, N-methyl-D-aspartate (NMDA) or kainate (KA), in acutely isolated rat cerebellar granule cell neurons, studied by flow cytometry. Various fluorescent dyes were used to monitor intracellular calcium concentration, ROS concentration, membrane potential, and viability in acutely dissociated neurons subjected to ischemia and reoxygenation alone… CONTINUE READING


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