Neuronal Ca2+ stores: activation and function.


The intracellular concentration of free Ca2+ ([Ca2+]i) displays complex fluctuations in response to a variety of stimuli, and acts as a pluripotent signal for many neuronal functions. It is well established that various 'metabotropic' neurotransmitter receptors can mediate the mobilization of Ca2+ stores via actions of inositol-polyphosphate second messengers, and more recent evidence suggests that 'ionotropic' receptor-mediated Ca2+ signals in neurones might also involve release of Ca2+ from intracellular stores. These two mechanisms of release of Ca2+ enable considerable temporal and spatial complexity of increases in the [Ca2+]i via multiple interactions at the level of intracellular-receptor activation. The complexity of Ca2+ signalling that is elicited via these interconnecting pathways might underlie mechanisms that are central to information transfer and integration within neuronal compartments.

Citations per Year

1,121 Citations

Semantic Scholar estimates that this publication has 1,121 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Simpson1995NeuronalCS, title={Neuronal Ca2+ stores: activation and function.}, author={Peter B. Simpson and R. A. John Challiss and Stefan R. Nahorski}, journal={Trends in neurosciences}, year={1995}, volume={18 7}, pages={299-306} }