Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc.

Abstract

CCCTC-binding factor (CTCF) is an organizer of higher-order chromatin structure and regulates gene expression. Genetic studies have implicated mutations in CTCF in intellectual disabilities. However, the role of CTCF-mediated chromatin structure in learning and memory is unclear. We show that depletion of CTCF in postmitotic neurons, or depletion in the… (More)
DOI: 10.1016/j.celrep.2016.11.004

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Cite this paper

@article{Sams2016NeuronalCI, title={Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc.}, author={Dev Sharan Sams and Stefano Nardone and Dmitriy Getselter and Dana Raz and Moran Tal and Prudhvi Raj Rayi and Hanoch Kaphzan and Ofir Hakim and Evan Elliott}, journal={Cell reports}, year={2016}, volume={17 9}, pages={2418-2430} }