Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice—Potential Link to Cognitive Impairment in Schizophrenia

@article{Chen2016NeuronalAS,
  title={Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice—Potential Link to Cognitive Impairment in Schizophrenia},
  author={Yong Chen and Sookhee Bang and Mary F. McMullen and Hala Altaf Kazi and Konrad Talbot and Mei-Xuan Ho and Greg Carlson and Steven E Arnold and Wei-Yi Ong and SangWon Kim},
  journal={Molecular Neurobiology},
  year={2016},
  volume={54},
  pages={1699-1709}
}
Schizophrenia is a chronic debilitating neuropsychiatric disorder that affects about 1 % of the population. Dystrobrevin-binding protein 1 (DTNBP1 or dysbindin) is one of the Research Domain Constructs (RDoC) associated with cognition and is significantly reduced in the brain of schizophrenia patients. To further understand the molecular underpinnings of pathogenesis of schizophrenia, we have performed microarray analyses of the hippocampi from dysbindin knockout mice, and found that genes… CONTINUE READING
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