Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome

@inproceedings{Kim2015NeuronwideRT,
  title={Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome},
  author={Sangmok Kim and Kelsey C Martin},
  booktitle={eLife},
  year={2015}
}
The persistence of experience-dependent changes in brain connectivity requires RNA localization and protein synthesis. Previous studies have demonstrated a role for local translation in altering the structure and function of synapses during synapse formation and experience-dependent synaptic plasticity. In this study, we ask whether in addition to promoting local translation, local stimulation also triggers directed trafficking of RNAs from nucleus to stimulated synapses. Imaging of RNA… CONTINUE READING
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