Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport.

  title={Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport.},
  author={Eric C Freundt and Nate Maynard and Eileen K. Clancy and Shyamali Roy and Luc Bousset and Yannick Sourigues and Markus Covert and Ronald Melki and Karla Kirkegaard and Michel Brahic},
  journal={Annals of neurology},
  volume={72 4},
OBJECTIVE The lesions of Parkinson disease spread through the brain in a characteristic pattern that corresponds to axonal projections. Previous observations suggest that misfolded α-synuclein could behave as a prion, moving from neuron to neuron and causing endogenous α-synuclein to misfold. Here, we characterized and quantified the axonal transport of α-synuclein fibrils and showed that fibrils could be transferred from axons to second-order neurons following anterograde transport. METHODS… CONTINUE READING