Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation


The cellular mechanisms underlying functional hyperemia—the coupling of neuronal activation to cerebral blood vessel responses—are not yet known. Here we show in rat cortical slices that the dilation of arterioles triggered by neuronal activity is dependent on glutamate-mediated [Ca2+]i oscillations in astrocytes. Inhibition of these Ca2+ responses resulted… (More)
DOI: 10.1038/nn980


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