Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene.

@article{Bloom1994NeuronspecificRO,
  title={Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene.},
  author={Debra Bloom and Jack G. Stevens},
  journal={Journal of virology},
  year={1994},
  volume={68 6},
  pages={3761-72}
}
We have previously shown that, when compared with either parent, a herpes simplex virus type 1/herpes simplex virus type 2 intertypic recombinant (R13-1) is attenuated by 10,000-fold with respect to neurovirulence in mice. Despite this, after intracranial inoculation, R13-1 replicated to titers of 10(5) PFU per brain. We present evidence that the… CONTINUE READING