Neuron-specific enolase is elevated in asymptomatic carriers of Leber's hereditary optic neuropathy.

@article{Yee2012NeuronspecificEI,
  title={Neuron-specific enolase is elevated in asymptomatic carriers of Leber's hereditary optic neuropathy.},
  author={Kenneth M. P. Yee and Fred N. Ross-Cisneros and Jeong Goo Lee and Arlon Bastos da Rosa and Solange R Salom{\~a}o and Adriana Berezovsky and Rubens J{\'u}nior Belfort and Filipe Chicani and Milton Nunes de Moraes-Filho and J Sebag and V Carelli and Alfredo Arrigo Sadun},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 10},
  pages={6389-92}
}
PURPOSE Neuron-specific enolase (NSE) is a biomarker for neuronal stress. Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease affecting retinal ganglion cells (RGC). These RGCs and their axons in the retinal nerve fiber layer (RNFL) and optic nerve head may show subclinical pathology in unaffected mutation carriers, or undergo cell death in affected patients. We hypothesize that increased levels of blood NSE may characterize LHON carriers as a biomarker of ongoing RGC stress… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
EyeNo subtypeRetina
Leber 's hereditary optic neuropathy ( LHON ) is a mitochondrial disease affecting retinal ganglion cells ( RGC ) .
These RGCs and their axons in the retinal nerve fiber layer ( RNFL ) and optic nerve head may show subclinical pathology in unaffected mutation carriers , or undergo cell death in affected patients .
EyeIs associated anatomic site ofOptic Atrophy, Hereditary, Leber
Leber 's hereditary optic neuropathy ( LHON ) is a mitochondrial disease affecting retinal ganglion cells ( RGC ) .
These RGCs and their axons in the retinal nerve fiber layer ( RNFL ) and optic nerve head may show subclinical pathology in unaffected mutation carriers , or undergo cell death in affected patients .
Leber 's hereditary optic neuropathy ( LHON ) is a mitochondrial disease affecting retinal ganglion cells ( RGC ) .
RetinaNo subtypeEye
These RGCs and their axons in the retinal nerve fiber layer ( RNFL ) and optic nerve head may show subclinical pathology in unaffected mutation carriers , or undergo cell death in affected patients .
Leber 's hereditary optic neuropathy ( LHON ) is a mitochondrial disease affecting retinal ganglion cells ( RGC ) .
RetinaAnatomic structure is physical part ofEye
These RGCs and their axons in the retinal nerve fiber layer ( RNFL ) and optic nerve head may show subclinical pathology in unaffected mutation carriers , or undergo cell death in affected patients .
Leber 's hereditary optic neuropathy ( LHON ) is a mitochondrial disease affecting retinal ganglion cells ( RGC ) .
These RGCs and their axons in the retinal nerve fiber layer ( RNFL ) and optic nerve head may show subclinical pathology in unaffected mutation carriers , or undergo cell death in affected patients .
Leber 's hereditary optic neuropathy ( LHON ) is a mitochondrial disease affecting retinal ganglion cells ( RGC ) .
Leber 's hereditary optic neuropathy ( LHON ) is a mitochondrial disease affecting retinal ganglion cells ( RGC ) .
Leber 's hereditary optic neuropathy ( LHON ) is a mitochondrial disease affecting retinal ganglion cells ( RGC ) .
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