Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy.

Abstract

OBJECTIVE Enduring, abnormal expression and function of the ion channel hyperpolarization-activated cyclic adenosine monophosphate gated channel type 1 (HCN1) occurs in temporal lobe epilepsy (TLE). We examined the underlying mechanisms, and investigated whether interfering with these mechanisms could modify disease course. METHODS Experimental TLE was… (More)
DOI: 10.1002/ana.22479

Topics

6 Figures and Tables

Cite this paper

@article{McClelland2011NeuronrestrictiveSF, title={Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy.}, author={Shawn McClelland and Corey Flynn and C{\'e}line M. Dub{\'e} and Cristina Richichi and Qinqin Zha and Antoine Ghestem and Monique Esclapez and Christophe Bernard and Tallie Z. Baram}, journal={Annals of neurology}, year={2011}, volume={70 3}, pages={454-64} }