Neuron loss in the nucleus basalis of Meynert in parkinsonism-dementia complex of Guam.

Abstract

The nucleus basalis of Meynert, which supplies diffuse cholinergic fibers to the cerebral neocortex, was investigated in two cases of parkinsonism-dementia complex of Guam (PDG). The nucleus basalis of the two PDG patients showed extensive neuron loss when compared with age-matched non-Guamanian controls, suggesting the necessity of investigating activity… (More)

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