Neuron-immune mechanisms contribute to pain in early stages of arthritis

  title={Neuron-immune mechanisms contribute to pain in early stages of arthritis},
  author={Francisco R Nieto and Anna K Clark and John Grist and Gareth J Hathway and V. Chapman and Marzia Malcangio},
  booktitle={Journal of Neuroinflammation},
Rheumatoid arthritis (RA) patients frequently show weak correlations between the magnitude of pain and inflammation suggesting that mechanisms other than overt peripheral inflammation contribute to pain in RA. We assessed changes in microglial reactivity and spinal excitability and their contribution to pain-like behaviour in the early stages of collagen-induced arthritis (CIA) model. Mechanically evoked hypersensitivity, spinal nociceptive withdrawal reflexes (NWRs) and hind paw swelling were… CONTINUE READING
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