Neuron-derived neurotrophic factor ameliorates adverse cardiac remodeling after experimental myocardial infarction.

@article{Joki2015NeuronderivedNF,
  title={Neuron-derived neurotrophic factor ameliorates adverse cardiac remodeling after experimental myocardial infarction.},
  author={Yusuke Joki and Koji Ohashi and Daisuke Yuasa and Rei Shibata and Yoshiyuki Kataoka and Takahiro Kambara and Yusuke Uemura and Kazuhiro Matsuo and Satoko Hayakawa and Mizuho Hiramatsu-Ito and Noriyoshi Kanemura and Masanori Ito and Hayato Ogawa and Hiroyuki Daida and Toyoaki Murohara and Noriyuki Ouchi},
  journal={Circulation. Heart failure},
  year={2015},
  volume={8 2},
  pages={
          342-51
        }
}
BACKGROUND Myocardial infarction (MI) is one of the major causes of death worldwide. Chronic heart failure is a serious complication of MI that leads to poor prognosis. We recently found that neuron-derived neurotrophic factor (NDNF) is a proangiogenic secretory protein that is upregulated in ischemic skeletal muscle. Here, we examined whether NDNF modulates cardiac remodeling in response to chronic ischemia. METHODS AND RESULTS C57BL/6J wild-type mice were subjected to the permanent ligation… CONTINUE READING

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