Neuron-derived IgG protects neurons from complement-dependent cytotoxicity.

@article{Zhang2013NeuronderivedIP,
  title={Neuron-derived IgG protects neurons from complement-dependent cytotoxicity.},
  author={Jie Zhang and Na Niu and Bingjie Li and Michael A. Mcnutt},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2013},
  volume={61 12},
  pages={
          869-79
        }
}
Passive immunity of the nervous system has traditionally been thought to be predominantly due to the blood-brain barrier. This concept must now be revisited based on the existence of neuron-derived IgG. The conventional concept is that IgG is produced solely by mature B lymphocytes, but it has now been found to be synthesized by murine and human neurons. However, the function of this endogenous IgG is poorly understood. In this study, we confirm IgG production by rat cortical neurons at the… CONTINUE READING
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