Neuromuscular responses of patients with multiple sclerosis.

  title={Neuromuscular responses of patients with multiple sclerosis.},
  author={Charles L Rice and Timothy L. Vollmer and Brenda Bigland-Ritchie},
  journal={Muscle & nerve},
  volume={15 10},
Muscle weakness, studied in 4 patients with multiple sclerosis (MS), was compared with values from normal subjects. Twitch occlusion showed that normal subjects could activate their muscles maximally, but patients rarely achieved greater than 60% activation. In both groups, motoneuron firing rates increased linearly with force. Consistent with the reduced level of activation, MCV firing rates in MS muscles rarely exceeded 17 Hz (compared with approximately 24 Hz for normals). However, for right… CONTINUE READING