Neuromuscular effects of G93A-SOD1 expression in zebrafish

  title={Neuromuscular effects of G93A-SOD1 expression in zebrafish},
  author={Stacey A. Sakowski and J. Simon Lunn and Angela S Busta and Sang Su Oh and Grettel J Zamora-Berridi and Madeline Palmer and Andrew A Rosenberg and Stephen G Philip and James J Dowling and Eva L. Feldman},
  booktitle={Molecular Neurodegeneration},
Amyotrophic lateral sclerosis (ALS) is a fatal disorder involving the degeneration and loss of motor neurons. The mechanisms of motor neuron loss in ALS are unknown and there are no effective treatments. Defects in the distal axon and at the neuromuscular junction are early events in the disease course, and zebrafish provide a promising in vivo system to examine cellular mechanisms and treatments for these events in ALS pathogenesis. We demonstrate that transient genetic manipulation of… CONTINUE READING