Neuromuscular dysfunction induced by acetylcholinesterase inhibition.

  title={Neuromuscular dysfunction induced by acetylcholinesterase inhibition.},
  author={Lynn Wecker and B Laskowski and Wolf D. Dettbarn},
  journal={Federation proceedings},
  volume={37 14},
The organophosphate cholinesterase inhibitor paraoxon produces a dose-dependent necrosis in rat skeletal muscle fibers after a single administration. The pathology, which is initiated at the motor end-plate region, is evident as early as 30 minutes after paraoxon administration and is characterized by dilated mitochondria, expanded sarcoplasmic reticulum, fused and widened subsynaptic folds, and coated cleft vesicles. By 24 hours, a generalized breakdown of muscle fiber architecture is evident… CONTINUE READING