Neuromuscular connectomes across development reveal synaptic ordering rules

@article{Meirovitch2021NeuromuscularCA,
  title={Neuromuscular connectomes across development reveal synaptic ordering rules},
  author={Yaron Meirovitch and Kai Kang and Ryan W. Draft and Elisa C. Pavarino and Maria Fernanda Henao Echeverri and Fuming Yang and Stephen G. Turney and Daniel R. Berger and Adi Peleg and Richard Schalek and Ju Lu and Juan Carlos Tapia and Jeff William Lichtman},
  journal={bioRxiv},
  year={2021}
}
The connections between motor neurons and muscle fibers are dramatically reorganized in early postnatal life. This work attempts to better understand this synaptic rewiring by using a connectomic approach, i.e., tracing out all the connections between motor neurons and muscle fibers, at successive ages in a small mouse muscle. We reconstructed 31 partial-complete neuromuscular connectomes, using serial section scanning electron microscopy in a neonatal mouse and Brainbow-based and XFP-based… 

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