Neuromuscular blocking property of amikacin in man.

@article{Hashimoto1978NeuromuscularBP,
  title={Neuromuscular blocking property of amikacin in man.},
  author={Y. Hashimoto and T. Shima and S. Matsukawa and M. Satou},
  journal={The Tohoku journal of experimental medicine},
  year={1978},
  volume={125 1},
  pages={
          71-5
        }
}
The effect of amikacin on the neuromuscular junction was studied in man during anesthesia and surgery. Amikacin alone did not show any neuromuscular blocking action in normal man in therapeutic doses (100-200 mg). However, during recovery from either d-tubocurarine block or phase II block with succinylcholine, the intravenous administration of 200 mg of amikacin caused a decrease in twitch tension. This neuromuscular block aggravated by amikacin was antagonized by edrophonium (10 mg) or calcium… Expand
4 Citations
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