Neuromuscular blocking property of amikacin in man.

  title={Neuromuscular blocking property of amikacin in man.},
  author={Y. Hashimoto and T. Shima and S. Matsukawa and M. Satou},
  journal={The Tohoku journal of experimental medicine},
  volume={125 1},
The effect of amikacin on the neuromuscular junction was studied in man during anesthesia and surgery. Amikacin alone did not show any neuromuscular blocking action in normal man in therapeutic doses (100-200 mg). However, during recovery from either d-tubocurarine block or phase II block with succinylcholine, the intravenous administration of 200 mg of amikacin caused a decrease in twitch tension. This neuromuscular block aggravated by amikacin was antagonized by edrophonium (10 mg) or calcium… Expand
4 Citations
Long-lasting potentiation of a single-dose of rocuronium by amikacin: case report.
Long-lasting (4 hours) potentiation of single intubating dose of rocuronium by a single bolus of amikacin given 55 minutes later in a woman having no precipitating factor is reported. Expand
Other antibiotic drugs
The stability of amikacin to most of the bacterial enzymes that inactivate gentamicin and tobramycin makes it an agent of first choice against aminoglycoside-resistant gram-negative bacteria. Expand
Neurotoxicity with antimicrobials in the elderly: a review.
A higher risk of developing various symptoms of neurotoxicity was found in the elderly with use of piperacillin and tazobactam, and the classes with the most reported cases include fluoroquinolones, macrolides, sulfonamides, nitrofurans, and β-lactams. Expand
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In einer prospektiv kontrollierten klinischen Studie wurden intraoperativ bei jeweils sechs Patienten pro Gruppe elektromyographisch Wechselwirkungen zwischen nicht-depolarisierendenExpand


Neuromuscular blocking properties of some antibiotics in man.
Neuromuscular blocking properties of ribostamycin (1 gm), dibecacin (100 mg) and tobramycin (60 mg) were studied in a man during anesthesia and surgery by observing the effects of these antibioticsExpand
The nature of the neuromuscular block produced by neomycine.
The neuromuscular block produced by neomycine has been studied in the rat diaphragm and the frog sartorius by means of intra- and extracellular recording techniques and it is found that the block is due to a reduction in the amplitude of the end-plate potential. Expand
Antibiotic‐Induced Paralysis
A clinically oriented analysis of the abstracts and a comprehensive bibliography comprise this review of medical literature over the past 15 years regarding neuromuscular blocking properties of certain antibiotic agents. Expand
Tobramycin-curare interaction.
A 59-year-old patient had urologic surgery under d-tubocurarine-fentanyl-N2O anesthesia. The muscle relaxant was reversed with prostigmine at the end of the 5-hour procedure. Reparalysis occurredExpand
[Assessment of residual curarization by train-of-four nerve stimulation].
Antibiotic blockade of neuromuscular function.
The neuromuscular blocking action of gentamicin.